Spatial transcriptomics reveals tumor-derived SPP1 induces fibroblast chemotaxis and activation in the hepatocellular carcinoma microenvironment
This study delineates the SPP1-CD44 signaling axis as a pivotal mechanism underpinning the interaction between tumor cells and CAFs. Targeting this pathway holds potential to mitigate liver fibrosis and offers novel therapeutic perspectives for liver cancer management.
Authors
- Zhongyang Shen (ORCID: https://orcid.org/0000-0001-9481-0407)
- Pinsheng Han (ORCID: https://orcid.org/0000-0003-1311-1802)
- Xingpeng Yang (ORCID: https://orcid.org/0000-0002-5351-1010)
- Wen Tong
- Tianze Wang (ORCID: https://orcid.org/0009-0001-3769-5147)
- Yamin Zhang (ORCID: https://orcid.org/0000-0003-0727-0540)
- Yi Bai (ORCID: https://orcid.org/0009-0007-6238-7262)
- Liuyang Zhu
Institutions
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Chinese PLA General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1186/s12967-024-05613-w
- Citations
- 41
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 11.69
Funders
- Natural Science Foundation of Tianjin City