Salivary DNA methylation derived estimates of biological aging, cellular frequency and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients
We provide evidence that the risk-related biological aging measure GrimAge may be a useful predictor of mucositis severity in HNC patients. Salivary monocyte frequency may be protective against mucositis, and this measure could be used as a predictive biomarker while also providing clues into the pathobiology of the disease.
Authors
- Ravi Kant Singh (ORCID: https://orcid.org/0000-0003-3073-2010)
- Christopher Thome (ORCID: https://orcid.org/0000-0002-0160-9657)
- Stacey A. Santi
- Chris P. Verschoor (ORCID: https://orcid.org/0000-0001-6190-2655)
- Deborah Saunders (ORCID: https://orcid.org/0000-0001-9499-4488)
- Sujeenthar Tharmalingam (ORCID: https://orcid.org/0009-0007-0415-4831)
Institutions
- Health Sciences North (CA)
- NOSM University (CA)
Publication Details
- Journal
- Oral Oncology
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1016/j.oraloncology.2024.107030
- Citations
- 7
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- Northern Ontario Academic Medicine Association