The Epstein–Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction
Although EBNA1 IgA was present in healthy sera, most epitopes localized to the immunodominant GAr. We conclude that a refined EBNA1 antigen deleted for the GAr, but with residues consistently detected in Southeast Asian NPC tumors, is optimized for risk prediction with an extended sojourn time of 7.5 years. Furthermore, distinct EBNA1 serologic profiles enhanced the utility of the EBNA1 IgA assay for risk stratification. This illustrates the importance of serologically relevant EBNA1 sequences for NPC risk prediction and early detection.
Authors
- Aks Chiang (ORCID: https://orcid.org/0000-0002-1089-5325)
- Woon‐Puay Koh (ORCID: https://orcid.org/0000-0002-5674-6341)
- Japan Patel
- Renwei Wang (ORCID: https://orcid.org/0000-0001-8871-7054)
- Jennifer Adams‐Haduch (ORCID: https://orcid.org/0000-0002-0640-3076)
- Kathy H.Y. Shair (ORCID: https://orcid.org/0000-0002-9556-1745)
- Yu‐Tang Gao (ORCID: https://orcid.org/0000-0003-3904-1777)
- Ka Wo Wong (ORCID: https://orcid.org/0009-0006-4042-7529)
- Jian‐Min Yuan (ORCID: https://orcid.org/0000-0002-4620-3108)
- Benjamin E. Warner (ORCID: https://orcid.org/0000-0002-1550-1516)
Institutions
- National University of Singapore (SG)
- University of Pittsburgh (US)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Department of Health (TW)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- National University Health System (SG)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1142
- Citations
- 6
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Institutes of Health