Development of a Peel-off Facial Mask Formula Containing Crude Extracts of Andrographis Paniculata

Introduction: The use of facial masks provides a viable alternative to the use of cold poultice in traditional medicine. However, with regard to the use of Andrographis paniculata in Thai traditional medicine, previous studies have not described an appropriate formula for such facial masks and their associated properties. The objective of this study is to describe the chemical and physical properties and contaminants found in six peel-off facial mask formulas containing Andrographis paniculata extracts. Methods: Investigators developed six formulas of facial masks containing Andrographis paniculata with varying amounts of PVA and HPMC but fixed proportion of crude Andrographis extract. Investigators then selected the formula with the most suitable properties for additional assessments regarding changes in their physical and chemical properties after a 3-month incubation period at varying temperatures, as well as chemical and microbial contaminations. Results: The most appropriate formula contained 2.5% HPMC (vol/vol) and 10% PVA (vol/vol). After incubation, formula at higher incubation temperature had lower andrographolite than formula at lower incubation temperature. The pH, colour, and thickness had little variations by incubation temperatures. Chemical and microbial contaminations were all according to standards. Discussion and Conclusion: The findings of the study had implications for stakeholders in pharmaceutical sciences and traditional medicine. However, limitations regarding the sample size and lack of generalizability should be considered in the interpretation of the study findings.