Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
Our preclinical studies demonstrate that immunotherapy via the innate immune system by combining tumor-targeting CAR-NK cells with an IL-15 agonist and a CD47 blockade is a promising novel therapeutic approach to targeting MCAM<sup>high</sup> malignant metastatic ES.
Authors
- Mitchell Stuart Cairo (ORCID: https://orcid.org/0000-0002-2075-434X)
- Wen Luo (ORCID: https://orcid.org/0000-0002-0621-2886)
- Janet Ayello
- Xiaokui Molly Mo (ORCID: https://orcid.org/0000-0002-9797-2687)
- Katherine E. Miller (ORCID: https://orcid.org/0000-0003-1108-2630)
- Timothy P. Cripe (ORCID: https://orcid.org/0000-0002-8595-3577)
- Dean A. Lee (ORCID: https://orcid.org/0000-0001-6693-5392)
- Hongwen Zhu (ORCID: https://orcid.org/0000-0002-2116-4245)
- Mark A. Currier (ORCID: https://orcid.org/0000-0002-0064-2025)
- Elaine R. Mardis (ORCID: https://orcid.org/0000-0002-5892-1553)
- Mario Q. Marcondes
- Shiori Eguchi (ORCID: https://orcid.org/0000-0002-9333-8208)
- Yanling Liao (ORCID: https://orcid.org/0000-0001-8493-0173)
- Meijuan Tian
- Hoang Hai (ORCID: https://orcid.org/0000-0001-5607-0794)
- Jeremy Rosenblum
Institutions
- Nationwide Children's Hospital (US)
- New York Medical College (US)
- Rasmussen College (US)
- Nektar Therapeutics (United States) (US)
- The Ohio State University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009726
- Citations
- 12
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- Pediatric Cancer Research Foundation
- University of Pennsylvania
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot