MiR-424-5p suppresses tumor growth and progression by directly targeting CHEK1 and activating cell cycle pathway in Hepatocellular Carcinoma
The present study demonstrates that miR-424-5p exerts a suppressive effect on HCC cell proliferation, migration, and invasion by downregulating the expression of CHEK1. This finding may offer a theoretical foundation for improving the prognosis and developing novel therapeutic strategies for HCC patients.
Authors
- Xianxian Zheng
- Yuansong Sun
- Chunlin Yin (ORCID: https://orcid.org/0000-0002-2391-3430)
- He Li (ORCID: https://orcid.org/0000-0001-9345-042X)
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37769
- Citations
- 4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Anhui Medical University