Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management

• Cisplatin resistance is a major challenge in oral cancer treatment, leading to poor outcomes. • Epigenetic factors such as DNA methylation, histone changes, and non-coding RNAs play key roles in resistance. • DNA methylation silences MGMT, impairing DNA repair and promoting resistance. • Combination therapy with epigenetic drugs and cisplatin may overcome resistance and improve outcomes.

Authors

Institutions

Publication Details

Journal
Oral Oncology Reports
Published
2024-09-01
DOI
https://doi.org/10.1016/j.oor.2024.100649
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management

Monisha Prasad, Ameerunnisha begum
Oral Oncology Reports
Histone Deacetylase Inhibitors Research
article

Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management

Monisha Prasad, Ameerunnisha begum
article en

Abstract

• Cisplatin resistance is a major challenge in oral cancer treatment, leading to poor outcomes. • Epigenetic factors such as DNA methylation, histone changes, and non-coding RNAs play key roles in resistance. • DNA methylation silences MGMT, impairing DNA repair and promoting resistance. • Combination therapy with epigenetic drugs and cisplatin may overcome resistance and improve outcomes.

Oral Oncology ReportsVol. 11
Saveetha University (IN)
Good health and well-being
Openalex Percentile: Top 86%
Histone Deacetylase Inhibitors Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Bridging the gap between epigenetics and cisplatin resistance: Implications for oral cancer management — Monisha Prasad, Ameerunnisha begum · Oral Oncology Reports (2024) | TGRS Research Map | TGRS