Die Grenzen der Bioinformatik in der Erforschung von archaeellen Viren

Abstract Archaeal viruses were studied by bioinformatics or isolation. While the accuracy of viral genome assemblies has improved through hybrid sequencing, this improvement is not observed in the prediction of gene functions due to missing homologs in databases. Therefore, further methods like powerful genetic systems are crucial to understand these viruses. A specific example is the system for MetSV, where the virus genome was cloned to create knockout mutants to better understand gene function.