Neu im Baukasten der synthetischen Biologen: Protein-bindende Aptamere

Abstract Progress in synthetic biology relies on developing new tools for circuit engineering. RNA aptamers, single stranded small RNA molecules, show promise by binding targets specifically. Aptamers targeting bacterial repressors offer new opportunity for conditional gene regulation. We develop aptamers that bind bacterial repressor proteins thereby activating repressor-controlled gene expression. These repressor-aptamer pairs significantly expand the synthetic biology tool box.