Benidipine Hydrochloride Inhibits NLRP3 Inflammasome Activation by Inhibiting LPS-Induced NF-κB Signaling in THP-1 Macrophages
Based on these results, we deduced that benidipine hydrochloride prevents ROS formation in THP-1 macrophages and LPS-induced NF-κB signaling, which in turn prevents the activation of NLRP3 inflammasomes and the release of IL-1β.
Authors
- Liqiong Ding (ORCID: https://orcid.org/0000-0003-0508-7531)
- Wanying Guo (ORCID: https://orcid.org/0000-0002-1636-0778)
- Mengmeng Huo
Institutions
- Hubei University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/jir.s467796
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Hubei University
- Hubei University of Science and Technology