Causal relationship between circulating immune cells and gastric cancer: a bidirectional Mendelian randomization analysis using UK Biobank and FinnGen datasets
Circulating CD4<sup>-</sup>CD8<sup>-</sup> T cells and IgD<sup>-</sup>CD27<sup>-</sup> B cells are positively correlated with the development of gastric cancer, while the percentage of IgD<sup>+</sup>CD24<sup>-</sup> B cells in lymphocytes are negatively correlated. These findings provide insight into the relationship between immune cells and gastric cancer pathogenesis and may serve as a basis for the development of immunotherapies for gastric cancer.
Authors
- Yang Ou
- Heng Du (ORCID: https://orcid.org/0000-0001-9067-0910)
- Lijuan You
- Weimin Yang (ORCID: https://orcid.org/0000-0001-7505-7122)
- Hui Luo
Institutions
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Guizhou Provincial People's Hospital (CN)
- Huanggang Central Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21037/tcr-24-480
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Health Commission of Hubei Province