Evaluation of microRNA-9 expression levels in Iraqi women patients with breast cancer

More information about the mechanisms underlying the pathophysiology of breast cancer (BC) is needed given the widespread epidemic of the disease and its detrimental effects on women's health. The relevance of microRNAs, also known as miRNAs or miRs, for breast cancer research, has lately become known due to the extensive number of risk agents connected to this cancer. The purpose of this study was to investigate whether microRNA-9 molecules expressed as early prognostic biomarkers for breast cancer detection.Twenty-five serum samples were obtained from women who had just been diagnosed with BC, and 25 serum samples were obtained from healthy women. On the other hand, qPCR was used to look at the expression of miR-9 in study groups.The miR-9 results revealed that serum BC patients had significantly higher (P<0.05) expression when compared to controls, with fold changes of 2.8 and 1.2, respectively.

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Publication Details

Journal
Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research
Published
2024-09-08
DOI
https://doi.org/10.21608/jbaar.2024.378590
Primary Topic
MicroRNA in disease regulation
Type
article
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article

Evaluation of microRNA-9 expression levels in Iraqi women patients with breast cancer

Ihab Q. Ali
Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research
MicroRNA in disease regulation
article

Evaluation of microRNA-9 expression levels in Iraqi women patients with breast cancer

Ihab Q. Ali
article en

Abstract

More information about the mechanisms underlying the pathophysiology of breast cancer (BC) is needed given the widespread epidemic of the disease and its detrimental effects on women's health. The relevance of microRNAs, also known as miRNAs or miRs, for breast cancer research, has lately become known due to the extensive number of risk agents connected to this cancer. The purpose of this study was to investigate whether microRNA-9 molecules expressed as early prognostic biomarkers for breast cancer detection.Twenty-five serum samples were obtained from women who had just been diagnosed with BC, and 25 serum samples were obtained from healthy women. On the other hand, qPCR was used to look at the expression of miR-9 in study groups.The miR-9 results revealed that serum BC patients had significantly higher (P<0.05) expression when compared to controls, with fold changes of 2.8 and 1.2, respectively.

Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research Vol. 10(3)
Gender equality
Openalex Percentile: Top 78%
MicroRNA in disease regulation
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