Long-Term Use of Proton Pump Inhibitors Increases the Risk of Renal Diseases

Proton pump inhibitors (PPIs) are drugs that successfully inhibit stomach acid secretion. It is used for the management of various acid-related conditions, including gastroesophageal reflux disease (GERD) and other gastric illnesses. It can reduce hydrochloric acid output via irreversible binding to the hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) and inhibiting its action in the stomach. PPIs are among the most often prescribed drugs, however, 25% to 70% of these prescriptions have no legitimate indication. As a result, patients frequently take these treatments without benefit exposing themselves to unwanted adverse events. PPIs can cause acute interstitial nephritis (AIN), which can be a serious side effect associated with acute kidney injury (AKI). It has been reported that using PPIs for a long time has been associated with an elevated risk of chronic kidney disease (CKD). As a result, this review aims to investigate the adverse effects of long-term use of PPIs on renal function