The prognosis and metabolite changes of NSCLC patients receiving first‐line immunotherapy combined chemotherapy in different M1c categories according to 9th edition of TNM classification
NSCLC patients in M1c1, devoid of driver gene mutations, receiving first-line PD-1 inhibitors combined with chemotherapy, experienced superior outcomes compared to M1c2 patients. Moreover, metabolomic profiles strongly correlated with the prognosis of these patients, and M1c2 patients with unfavorable outcomes manifested distinct changes in metabolic pathways before treatment. These changes predominantly involved alterations in lipid metabolism, such as decreased diacylglycerol and sphingomyelin, which may impact tumor migration and invasion.
Authors
- Runbo Zhong (ORCID: https://orcid.org/0000-0003-4616-1224)
- Baohui Han (ORCID: https://orcid.org/0000-0002-3950-3030)
- Jun Lu (ORCID: https://orcid.org/0000-0002-9347-7793)
- Fang Hu (ORCID: https://orcid.org/0000-0002-5343-4596)
- Xueyan Zhang (ORCID: https://orcid.org/0000-0001-7212-3593)
- Hua Zhong (ORCID: https://orcid.org/0009-0003-2680-8497)
- Liang Zheng (ORCID: https://orcid.org/0000-0002-1464-9500)
- Tianqing Chu (ORCID: https://orcid.org/0000-0002-1383-0383)
- Wei Nie (ORCID: https://orcid.org/0000-0002-5912-4804)
- Yinchen Shen (ORCID: https://orcid.org/0000-0002-1214-711X)
- Shuyuan Wang (ORCID: https://orcid.org/0000-0002-1232-821X)
- Ying Li (ORCID: https://orcid.org/0000-0002-0438-449X)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-7167-4083)
- Xiaoxuan Zheng (ORCID: https://orcid.org/0009-0006-5986-0365)
- Jianlin Xu
- Wei Zhang (ORCID: https://orcid.org/0000-0002-5467-6263)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Chest Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.70223
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Fundamental Research Funds for the Central Universities