The Trajectory of Gliflozins: From Apple Tree Bark to Reduced Overall Mortality in Heart Failure

A small number of drugs have been responsible for major advances in medical practice throughout history, for instance, the discovery of penicillin, insulin, aspirin, and statins. Diabetes treatment began with parenteral insulin, discovered by Banting and Bet approximately a century ago; since then, several classes of oral medications that improve glycemic control have been developed and become available for widespread use. More recently, sodium-glucose cotransporter inhibitors have emerged, with a surprising impact and effect on the treatment of patients [...]