Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8<sup>+</sup> T cell infiltration
Endosialin could inhibit CD8<sup>+</sup> T cell infiltration by inhibiting the expression and secretion of CXCL9/10 in CAFs, thus promote HCC progression. Combination therapy with endosialin antibody could increase the antitumor effect of PD-1 antibody in HCC, which may overcome the resistance to PD-1 blockade.
Authors
- Hongtao Song (ORCID: https://orcid.org/0009-0007-4113-7432)
- Keying Zhang (ORCID: https://orcid.org/0000-0002-4615-1782)
- Yu Lu
- Jiayu Zhang (ORCID: https://orcid.org/0000-0002-6898-6844)
- Xinjie Wu
- Shiqi Lu (ORCID: https://orcid.org/0000-0001-7168-7813)
- Weihong Wen (ORCID: https://orcid.org/0000-0003-4739-4871)
- Fa Yang
- Tong Lü (ORCID: https://orcid.org/0000-0001-5691-9209)
- Donghui Han (ORCID: https://orcid.org/0000-0002-3742-4355)
- Lunbiao Gan (ORCID: https://orcid.org/0009-0009-4394-0565)
- Weijun Qin (ORCID: https://orcid.org/0000-0002-7509-7164)
- Fengze Nie
- Sijia Di
Institutions
- Northwestern Polytechnical University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/jitc-2024-009111
- Citations
- 13
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- National Natural Science Foundation of China