Multiomic Profiling and Neuroprotective Bioactivity of Salvia Hairy Root-Derived Extracellular Vesicles in a Cellular Model of Parkinson’s Disease
Collectively, our findings provide compelling evidence that EVs isolated from the hairy roots of <i>Salvia s</i>pecies are promising, non-mammalian alternative for the design of novel therapies targeting neurological disorders.
Authors
- Mariaevelina Alfieri (ORCID: https://orcid.org/0000-0002-9594-1342)
- María Moros (ORCID: https://orcid.org/0000-0002-2861-2469)
- Alfredo Ambrosone (ORCID: https://orcid.org/0000-0002-1897-4028)
- Valentina Santoro (ORCID: https://orcid.org/0000-0003-0859-8230)
- Vincenzo Vestuto (ORCID: https://orcid.org/0000-0002-3603-5526)
- Chiara Amante (ORCID: https://orcid.org/0000-0002-2906-6500)
- Giacomo Pepe (ORCID: https://orcid.org/0000-0002-7561-2023)
- Matteo Delli Carri (ORCID: https://orcid.org/0000-0002-1921-1516)
- Francesca Mensitieri (ORCID: https://orcid.org/0000-0002-5062-313X)
- Elisa Cappetta
- Fabrizio Dal Piaz (ORCID: https://orcid.org/0000-0002-8643-5018)
- Ornella Moltedo (ORCID: https://orcid.org/0000-0002-0526-2152)
- Pietro Campiglia (ORCID: https://orcid.org/0000-0002-1069-2181)
- Nunziatina De Tommasi (ORCID: https://orcid.org/0000-0003-1707-4156)
- Antonietta Leone (ORCID: https://orcid.org/0000-0002-7236-8010)
- Marisa Conte (ORCID: https://orcid.org/0000-0002-7649-2860)
- Maria Rosaria Miranda (ORCID: https://orcid.org/0009-0005-8296-1888)
- Pasquale Del Gaudio
- Anna Di Muro
- Mariapia Vietri
Institutions
- University of Salerno (IT)
- Universidad de Zaragoza (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Santobono Children's Hospital (IT)
- Instituto de Nanociencia y Materiales de Aragón (ES)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- University of Palermo (IT)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/ijn.s479959
- Citations
- 20
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- European Commission
- Umm Al-Qura University