Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
Based on network pharmacology, molecular docking and experimental verification, this study demonstrated that QSHT could improve cardiac function and attenuate cardiac fibrosis by regulating TLR4/NF-κB and AKT/HIF-1α signaling pathway in post- MI and high-fat diet ApoE<sup>-/-</sup> mice.
Authors
- Xiaomin Ou (ORCID: https://orcid.org/0000-0003-1259-0581)
- Xiaolan Kuang
- Yunshan Wu
- Weihui Lu (ORCID: https://orcid.org/0000-0001-7754-2682)
- Hua Yang (ORCID: https://orcid.org/0000-0003-4993-7796)
- Bo Liu (ORCID: https://orcid.org/0000-0002-9539-2005)
- Lin Jiao (ORCID: https://orcid.org/0000-0001-5861-2585)
- Haoxiang Li (ORCID: https://orcid.org/0000-0002-7828-3456)
- Tao-Hua Lan (ORCID: https://orcid.org/0000-0002-5393-9009)
- Chunxia Yin
- Jing Cai
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Ji Hua Laboratory (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/dddt.s463054
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Traditional Chinese Medicine Bureau of Guangdong Province