The Effects Of Enamel Matrix Derivative On Periodontal Patients

OBJECTIVES: The purpose of this literature review was to describe enamel matrix derivative (EMD) and how it benefits periodontal patients. EMD's rejuvenating abilities were identified as well as the different functions of EMD. METHODS: Articles chosen for this literature review were randomized control trials that were peer reviewed and published within the last five years. PubMed was accessed through Augusta University's database for research. Keywords used to search included enamel matrix derivative, bone loss, periodontitis, enamel matrix proteins, gum disease, regeneration, therapy, and growth. RESULTS: Studies chosen for this literature review all showed that EMD improves clinical attachment level. It is able to promote hard and soft tissue regeneration because it contains the same proteins that are involved in amelogenesis. These proteins stimulate fibroblasts, anti-inflammatory cytokines, and clotting factors. All these factors make EMD a great adjunct to periodontal surgical procedures. EMD is also able to reduce inflammation, promote wound healing, and stabilize blood clots. CONCLUSIONS: Overall, EMD's ability to assist in the formation of new bone, cementum, and periodontal ligaments makes it an excellent treatment option for periodontally involved patients. It is frequently used with scaling and root planing, flap surgery, and the treatment of infrabony defects.