Efficacy of Ozone Therapy in Periodontal Disease Compared to SRP

OBJECTIVES: The objective of the present study was to find out the benefit of ozonized therapy as an adjunct to nonsurgical periodontal therapy for the management of periodontitis. METHODS: A specific collection of available literature was selected and reviewed on the topic of ozone therapy and periodontal disease. Ozone Therapy, Ozone gas, Oxygen, Ozone [MeSH], Periodontitis, alveolar bone loss, Periodontal Disease [MeSH] werev the specific keywords and MeSH terms we used.Regarding the selection criteria for articles, only peer-reviewed articles published within the last five years were considered. Excluded were literature reviews, meta-analyses, books, or documents. However, randomized controlled trials, whether clinical or not, were accepted. RESULTS: All evaluated studies show the positive outcome of ozone therapy as an adjunct to SRP. Adjunctive ozone therapy resulted in significant improvement in all except one. The first study shows no significant difference in the outcome of both groups in evaluating GCF, PTX-3, IL-1B, and high-sensitivity C-reactive proteins. In the other two studies, clinical parameters of bacterial load, periodontal pocket depth, T. forsythia and T. denticola were decreased and completely eradicated . The total bacteria load and P. gingivalis showed a percentage reduction of 38% and 55% concerning the right-side pockets, respectively. CAL, BOP, and PPD response rates after three months and six months also reduced significantly in the test group after therapy. CONCLUSIONS: Ozone therapy essentially introduces oxygen into an environment where it usually does not exist. Therefore, it disrupts the stability, replication, and energy source of destructive pathogens. IMPLICATIONS: The implication of ozone therapy lies in its ability to effectively eliminate periodontal pathogens, particularly anaerobic bacteria like spirochetes and P. gingivalis.