Box-Behnken Response Surface Design for the Optimization of a High-Performance Electrochemical Dopamine Sensor Based on Novel Nano-Ag Doped Matériaux Institut Lavoisier Metal-Organic Framework 101 (MIL-101-Cr) Composite Modified Glassy Carbon Electro

The combination of metal-organic frameworks (MOFs) and metal nanoparticles offers great prospects for improving the electrochemical properties of sensors. In this paper, silver (Ag) nanoparticle-doped metal-organic framework (MIL-101) composites (Ag-MIL-101) were prepared by ultrasonic treatment of MIL-101 and the reduction of the metal precursor (AgNO3) within the MIL-101 material. X-ray diffraction patterns confirmed the formation of Ag-MIL-101(Cr). The resulting material was used to construct a new electrochemical sensor for the reliable detection of dopamine. The electrochemical response of the developed sensor toward dopamine was evaluated using differential pulse voltammetry. A Box-Behnken design was performed, and response surface methodology was used to study the influence of different parameters on dopamine detection. The response of the modified electrode for dopamine detection was linear in the range from 0.02 μM to 10 μM, and the detection limit was 0.02 μM (S/N = 3). Additionally, it showed high selectivity in the presence of urea, uric acid, ascorbic acid, and L-arginine. Due to its low cost, easy process, and great performance, this Ag-MIL-101/GCE electrode can be a good candidate for the fabrication of a non-enzymatic dopamine sensor.