Overcoming drug-resistant tumors with selection gene drives
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.<sup>1</sup> engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable killing efficacies in preclinical models using human non-small lung cancer cells in vitro and in mice, this work describes an attractive mindset to develop next-generation anticancer therapies.
Authors
- Mingqi Xie (ORCID: https://orcid.org/0000-0001-5657-532X)
- Hui Wang (ORCID: https://orcid.org/0000-0002-3266-2055)
Institutions
- Westlake University (CN)
- Zhejiang Lab (CN)
Publication Details
- Journal
- Cell Genomics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.xgen.2024.100653
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tencent
- Westlake University
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China