Mutational Features and Tumor Microenvironment Alterations in High-Grade Appendiceal Cancers Treated With Iterative Hyperthermic Intraperitoneal Chemotherapy
HIPEC-associated mutational signatures were identified in HGAA-PMs. Elevated PD-L1+ cytotoxic T-cell populations after HIPEC had better PFS, offering valuable insights for prognostication in the context of HIPEC treatment.
Authors
- Yuanyuan Zha (ORCID: https://orcid.org/0000-0002-0574-7352)
- Varun Bansal (ORCID: https://orcid.org/0000-0002-9973-0884)
- Kiran K. Turaga (ORCID: https://orcid.org/0000-0001-8541-586X)
- Blasé N. Polite (ORCID: https://orcid.org/0000-0001-8743-8096)
- Oliver S. Eng (ORCID: https://orcid.org/0000-0003-0226-5005)
- Ankit Dhiman (ORCID: https://orcid.org/0000-0003-3086-2587)
- Lindsay Alpert (ORCID: https://orcid.org/0000-0002-3599-8830)
- Ardaman P. Shergill (ORCID: https://orcid.org/0000-0002-8244-2704)
- David Su (ORCID: https://orcid.org/0000-0002-8693-612X)
Institutions
- University of California, Irvine (US)
- Augusta University (US)
- Yale University (US)
- University of Chicago Medical Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1200/po.24.00149
- Citations
- 3
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Organization for Rare Disorders
- Yale University
- Yale Cancer Center
- National Institutes of Health