Zinc-alpha2-glycoprotein modulates blood pressure by regulating renal lipid metabolism reprogramming-mediated urinary Na+ excretion in hypertension
Deficiency of Azgp1 increased the malonyl CoA-mediated inhibition of CPT1 activity, leading to renal lipid metabolism reprogramming, resulting in accumulated fatty acids and increased NHE activity, subsequently decreasing urinary Na+ excretion and causing hypertension. These findings may provide a potential kidney-targeted therapy in the prevention and treatment of hypertension.
Authors
- Valérie B Schini-Kerth
- Cheng‐Feng Du (ORCID: https://orcid.org/0000-0002-5598-476X)
- Lifu Lei
- Caiyu Chen
- Jian Yang (ORCID: https://orcid.org/0000-0003-2954-758X)
- Xiaoliang Wang (ORCID: https://orcid.org/0000-0002-7870-2729)
- Lin Chen (ORCID: https://orcid.org/0000-0002-1108-4735)
- Zhou Xiaoxin (ORCID: https://orcid.org/0009-0002-1652-408X)
- Shuo Zheng (ORCID: https://orcid.org/0009-0005-7347-3188)
- Chunyan Deng (ORCID: https://orcid.org/0000-0001-5581-9417)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Third People 's Hospital of Chongqing (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Université de Strasbourg (FR)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1093/cvr/cvae205
- Citations
- 7
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 7.76
Funders
- National Natural Science Foundation of China
- Chongqing Medical University