Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression
Our study revealed that over-supplementation with FA during mouse pregnancy is detrimental to cardiac function with the decreased left ventricular ejection fraction in the offspring and provides insights into the mechanisms underlying the association between maternal FA status and health outcomes in the offspring.
Authors
- Hao‐Ran Geng
- Jia-Quan Lu
- Ke Cai (ORCID: https://orcid.org/0000-0001-9586-6912)
- Yan Shi
- Yonghao Gui (ORCID: https://orcid.org/0000-0002-5043-5534)
- Feng Wang (ORCID: https://orcid.org/0000-0002-4591-3888)
- Jian‐Yuan Zhao (ORCID: https://orcid.org/0000-0001-9861-0330)
- Anna Shen (ORCID: https://orcid.org/0000-0003-2247-1957)
- Rui Zhao (ORCID: https://orcid.org/0000-0003-0423-2039)
- Hai-Qun Shi (ORCID: https://orcid.org/0009-0005-4572-3696)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Zhengzhou University (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1093/cvr/cvae203
- Citations
- 7
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 7.76
Funders
- National Natural Science Foundation of China
- Fudan University
- National Key Research and Development Program of China