Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy
Our findings unravelled that dysfunctional goblet cells and consequential bacterial translocation activated the S100A11-RAGE axis in right-sided colon ADs, which recruits MDSCs to promote immune evasion. Targeting this axis by Azeliragon improves the efficacy of immunotherapy in colon cancer.
Authors
- Chuangen Li (ORCID: https://orcid.org/0000-0002-1977-4298)
- Haijun Deng (ORCID: https://orcid.org/0000-0002-4890-192X)
- Chi Chun Wong (ORCID: https://orcid.org/0000-0003-1362-3541)
- Baoxiong Zhuang
- Qiming Zhou (ORCID: https://orcid.org/0000-0001-9945-0084)
- Xuehua Zhang (ORCID: https://orcid.org/0000-0002-6923-2008)
- Yuyang Du
- Guoxin Li (ORCID: https://orcid.org/0000-0003-2773-7048)
- Junyou Chen (ORCID: https://orcid.org/0000-0002-8989-0518)
- Linhan Lei
- Qing Li (ORCID: https://orcid.org/0000-0002-0169-8098)
- Xiaowu Bai (ORCID: https://orcid.org/0000-0001-8377-0518)
- Junhong Cheng
Institutions
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- University of Macau (MO)
- Nanfang Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Southern Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Gut
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1136/gutjnl-2024-332193
- Citations
- 18
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- National Natural Science Foundation of China