Anti-diabetic Effect of Opuntia humifusa Extracts in Diabetic db/db Mice

Background: This study examined the anti-diabetic effects of Opuntia. humifusa extract (OHE) in diabetic db/db mice.<br/>Methods and Results: The 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity and α- glucosidase and α-amylase inhibitory activities of OHE (oral administration for 4 weeks) was evaluated using biochemical parameters and histological analyses of the pancreas. Oral administration of OHE reduced plasma glucose and fructosamine levels, without affecting body weight or food intake. Additionally, it improved blood lipid parameters and restored the of islet structure in diabetic db/db mice.<br/>Conclusion: The present study provides evidence for the anti-diabetic effect of OHE in db/db mice. These results suggest that OHE can be used as a medicinal supplement or functional foods for anti-diabetic therapy.