Monkeypox: A Global Challenge - An Overview

Monkeypox is a zoonosis caused by an orthopoxvirus named monkeypox virus MPX, structurally related to smallpox virus, enveloped, brick shaped, replicates in cytoplasm. Currently spreading throughout Africa & different parts of world. Has two distinct clades, West African and Central African (Congo Basin) clades. It manifests as rashes, concentrated on face & extremities like palms & soles. Both humoral and cell mediated immunity are seen in host, diagnosed by polymerase chain reaction PCR and various serological tests. Patients receive supportive treatments along with antiviral drugs. Presently FDA approved new Mpox vaccines. Scientific community needs to extend their research work to enhance knowledge in this field. This review briefs about monkeypox in human life in context of ongoing outbreaks around the world.