Association between fasting lipid profile, inflammatory markers and oxidative stress markera burden of cardiovascular risk in postmenopausal women with high Body Mass Index

Cardiovascular diseases are becoming more successful in the entire population of individuals and is the leading cause of death in both men and women. The effect of cardiovascular disease is not appreciated high enough in women when set side by side in men. Women have eccentric variable determinants that increases the probability of cardiovascular diseases and postmenopausal women are at higher risk of developing cardiovascular diseases. Postmenopause is the time when menstrual period stops permanently in a women’s life. Several hormonal imbalances as well as metabolic changes make them more prone for cardiovascular diseases. Fasting lipid profile, inflammatory markers like hs-CRP, TNF-α, Adiponectin and oxidative stress marker like Malondialdehyde are found altered in high BMI postmenopausal women and this altered parameters tend to become a major CV risk. Aim and objective. The aim is to associate the levels of fasting lipid profile, inflammatory markers like hs-CRP, TNF-α, Adiponectin and oxidative stress marker like Malondialdehyde with cardiovascular disease in normal and high BMI postmenopausal women. Materials and methods. The research was directed on 104 postmenopausal women of age group 45–60 years and we grouped them into 2. Group 1 having normal BMI (18.50–24.99) and group 2 having high BMI > 25.00 based on Asian’s classification for BMI. Approval from the Institutional Ethical Committee was obtained before beginning the study. Postmenopausal women were instructed to report to physiology department at 7.30 am following overnight fasting and 5 ml of blood was collected to assess their fasting lipid profile, oxidative stress marker and inflammatory markers. Results & conclusion. Unpaired t-test was used to analyse all parameters of the study (control and study group). BMI, Total Cholesterol, Triacylglycerol, LDL-C, VLDL-C, hs-CRP, TNF-α, Malondialdehyde were significantly elevated and the levels of HDL-C and adiponectin were found reduced in high BMI postmenopausal women when compared to normal BMI postmenopausal women (p < 0.05) and all these factors are reported to be risk factors for adverse CV events.