A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia

Our data point to microglia as a new cell target through which NGF-induced TrkA signalling exerts neuroprotection of the RGC, emphasizing hNGFp as a powerful treatment to tackle retinal degeneration.

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Publication Details

Journal
British Journal of Pharmacology
Published
2024-09-09
DOI
https://doi.org/10.1111/bph.17316
Citations
3
Primary Topic
Nerve injury and regeneration
Type
article
Field-Weighted Citation Impact
0.80

Funders

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article

A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia

Pierangelo Geppetti, Elena Novelli, Gino Villetti, Alessio Canovai et al.
3 citations
British Journal of Pharmacology
Nerve injury and regeneration
0.80
article

A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia

Pierangelo Geppetti, Elena Novelli, Gino Villetti, Alessio Canovai, Silvia Marinelli, Laura Latini, Hiroki Asari, Antonino Cattaneo, Francesca Malerba, Simona Capsoni, Rosario Amato, Rita Florio, Ivan Arisi, Lucia Buccarello, Massimo Dal Monte, Romina Nassini, Francesco De Logu, Daniel Souza Monteiro de Araújo, Bruno Pietro Imbimbo, Enrica Strettoi, Anastasiia Vlasiuk
article en
3 citations

Abstract

Our data point to microglia as a new cell target through which NGF-induced TrkA signalling exerts neuroprotection of the RGC, emphasizing hNGFp as a powerful treatment to tackle retinal degeneration.

British Journal of PharmacologyVol. 181(23)
University of Pisa (IT), Scuola Normale Superiore (IT), University of Ferrara (IT), Heidelberg University (DE), European Molecular Biology Laboratory (IT), European Brain Research Institute (IT), National Research Council (IT), Chiesi (Italy) (IT), University of Florence (IT)
Chiesi Farmaceutici, Ministero della Salute, Center for Neuroscience Research
Good health and well-being
Openalex Percentile: Top 29%
Nerve injury and regeneration
0.80
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