A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia
Our data point to microglia as a new cell target through which NGF-induced TrkA signalling exerts neuroprotection of the RGC, emphasizing hNGFp as a powerful treatment to tackle retinal degeneration.
Authors
- Pierangelo Geppetti (ORCID: https://orcid.org/0000-0003-3797-8371)
- Elena Novelli (ORCID: https://orcid.org/0000-0002-6588-4930)
- Gino Villetti
- Alessio Canovai (ORCID: https://orcid.org/0009-0007-9229-4710)
- Silvia Marinelli (ORCID: https://orcid.org/0000-0003-2620-8371)
- Laura Latini (ORCID: https://orcid.org/0000-0001-6480-0355)
- Hiroki Asari (ORCID: https://orcid.org/0000-0003-3396-1935)
- Antonino Cattaneo (ORCID: https://orcid.org/0000-0002-6975-8923)
- Francesca Malerba (ORCID: https://orcid.org/0000-0002-8635-8622)
- Simona Capsoni (ORCID: https://orcid.org/0000-0003-2670-8237)
- Rosario Amato (ORCID: https://orcid.org/0000-0002-8386-4714)
- Rita Florio
- Ivan Arisi (ORCID: https://orcid.org/0000-0002-0536-2508)
- Lucia Buccarello (ORCID: https://orcid.org/0000-0002-3393-653X)
- Massimo Dal Monte (ORCID: https://orcid.org/0000-0002-5181-4456)
- Romina Nassini (ORCID: https://orcid.org/0000-0002-9223-8395)
- Francesco De Logu (ORCID: https://orcid.org/0000-0001-8360-6929)
- Daniel Souza Monteiro de Araújo (ORCID: https://orcid.org/0000-0003-1115-725X)
- Bruno Pietro Imbimbo (ORCID: https://orcid.org/0000-0002-0327-7262)
- Enrica Strettoi (ORCID: https://orcid.org/0000-0002-6101-599X)
- Anastasiia Vlasiuk
Institutions
- University of Pisa (IT)
- Scuola Normale Superiore (IT)
- University of Ferrara (IT)
- Heidelberg University (DE)
- European Molecular Biology Laboratory (IT)
- European Brain Research Institute (IT)
- National Research Council (IT)
- Chiesi (Italy) (IT)
- University of Florence (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1111/bph.17316
- Citations
- 3
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Chiesi Farmaceutici
- Ministero della Salute
- Center for Neuroscience Research