Research hotspots and trend analysis of embryonic stem cell therapy based on bibliometric analysis

Objectives: This article was designed to deeply analyze the research status and frontier trend of embryonic stem cells (ESCs) therapy, and accurately understand the development stage and characteristics of ESCs therapy research. Methods: By entering keywords, downloading literature, applying bibliometric analysis software, and website, research trends in ESCs therapy from 2015 to 2024 were analyzed, covering annual trends, countries or regions, institutions, and authors. Results: The analysis reveals a general decline in publication volume since 2018, with stabilization observed in recent years, indicating ongoing scholarly interest in ESC research. The United States and China emerged as leading contributors, with China showing rapid growth since 2015. American institutions, particularly Harvard University, lead in publication volume, while the University of Cambridge stands out for its high citation impact. Prominent authors like Meissner Alexander play a central role in advancing the field through extensive collaboration. Key journals, including Cell Stem Cell and Nature, dominate ESC research publications. Conclusions: In the field of ESCs therapy, other countries need to make efforts to keep up with the United States, and try to innovate and expand the contents of stem cell studies. In summary, this article conducts a systematic review and trend outlook of stem cell-related studies, exploring current research trends and hotspots and emphasizing the importance of international collaboration and quality-driven research in ESCs.