Bailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice
The findings of this study demonstrate that Bailixiang tea possesses the ability to alleviate lung tissue damage and inhibit the development of LPS-induced cytokine storm in mice. These effects are attributed to the tea's ability to suppress the TLR2/MAPK8 and TLR2/NF-κB pathways. Consequently, this research highlights the potential application of Bailixiang tea as a treatment option for cytokine storm.
Authors
- Hongjun Yang
- Xiaoang Zhao
- Chunhui Zhao (ORCID: https://orcid.org/0000-0003-1444-2574)
- Youming Li (ORCID: https://orcid.org/0000-0002-9497-6762)
- Jixiang Tian
- Xianyu Li (ORCID: https://orcid.org/0000-0001-9625-8476)
- Yun Wang (ORCID: https://orcid.org/0000-0001-7146-8290)
- Fengrong Zhang (ORCID: https://orcid.org/0000-0002-6530-9442)
- Mei Liu
- Xingyue Xu
- Dewen Liu
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.jep.2024.118791
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Ministry of Science and Technology of the People's Republic of China
- China Academy of Chinese Medical Sciences