Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells
Inhibited Nrf2 activity can reduce the downstream antioxidant enzyme HO-1 and antioxidant levels, induce NLRP3 inflammasome activation and ASC protein assembly in microglia, and ultimately aggravate PD inflammatory response and dopamine neuron degeneration.
Authors
- Xinling Yang (ORCID: https://orcid.org/0000-0002-4517-0500)
- Lijie Zhang (ORCID: https://orcid.org/0000-0002-9435-9799)
- Ranran Lu (ORCID: https://orcid.org/0000-0001-5172-5018)
- Xu Zhou (ORCID: https://orcid.org/0009-0009-5077-5668)
- Mengdie Hao
Institutions
- Xinjiang Medical University (CN)
- Xinjiang Production and Construction Corps (CN)
- Xinjiang Institute of Engineering (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/jir.s478683
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- National Natural Science Foundation of China