Nadolol Attenuates Brain Cell Ferroptosis in Ischemic Stroke Rats by Targeting the HOIL-1/IRP2 Pathway
In terms of these findings, it is concluded that nadolol can protect the ischemic rats' brains against ferroptosis by targeting the HOIL-1/IRP2 pathway, thereby preventing intracellular iron overload. Thus, nadolol may be a novel indication for treating patients with ischemic stroke.
Authors
- Xiaoyan Yang (ORCID: https://orcid.org/0000-0001-7928-2554)
- Xiu‐Ju Luo (ORCID: https://orcid.org/0000-0002-4605-0148)
- Wenjun Zhu (ORCID: https://orcid.org/0000-0002-9026-7221)
- Di-Chen
- Dan Peng (ORCID: https://orcid.org/0000-0002-7917-2133)
- Jun Peng (ORCID: https://orcid.org/0000-0003-2590-0024)
- Zhijun Zhou (ORCID: https://orcid.org/0000-0002-2407-2071)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- CNS & Neurological Disorders - Drug Targets
- Published
- 2024-09-10
- DOI
- https://doi.org/10.2174/0118715273308006240822165146
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.42