Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension
Metformin modulated the gut microbiome, increased SCFA production, and ameliorated blood pressure and cardiac remodeling in dTGR. Our findings confirm the protective effects of metformin in the absence of diabetes, highlighting SCFA as a potential mediators.
Authors
- Valentin Vecera
- Burkhard Kleuser (ORCID: https://orcid.org/0000-0002-1888-9595)
- Wolfram Gronwald (ORCID: https://orcid.org/0000-0003-3646-0060)
- Theda Ulrike Patricia Bartolomaeus (ORCID: https://orcid.org/0000-0002-5156-7184)
- Nicola Wilck (ORCID: https://orcid.org/0000-0003-3189-5364)
- Nadine Haase (ORCID: https://orcid.org/0000-0003-0727-1738)
- Olena Potapenko (ORCID: https://orcid.org/0000-0002-4397-568X)
- Lucas Stürzbecher
- Sarah Kedziora (ORCID: https://orcid.org/0000-0003-0124-2557)
- M Samaan (ORCID: https://orcid.org/0009-0008-5924-3732)
- Arne Thiele (ORCID: https://orcid.org/0000-0003-0786-2239)
- Harithaa Anandakumar (ORCID: https://orcid.org/0009-0000-3326-5126)
- Sofia Kirke Forslund (ORCID: https://orcid.org/0000-0003-4285-6993)
- Fabian Schumacher (ORCID: https://orcid.org/0000-0001-8703-3275)
- Sabrina Geisberger (ORCID: https://orcid.org/0000-0001-6477-1312)
- Moritz I. Wimmer (ORCID: https://orcid.org/0009-0004-5793-0249)
- Hendrik Bartolomaeus (ORCID: https://orcid.org/0000-0003-4288-3828)
- Ulrike Löber (ORCID: https://orcid.org/0000-0001-7468-9531)
- Ariana Rauch (ORCID: https://orcid.org/0000-0002-5152-5830)
- Peter Josef Oefner (ORCID: https://orcid.org/0000-0002-1499-3977)
- Dominik N. Müller (ORCID: https://orcid.org/0000-0003-3650-5644)
- Alex Yarritu (ORCID: https://orcid.org/0000-0002-1724-0559)
- Chia‐Yu Chen (ORCID: https://orcid.org/0000-0003-1765-7132)
- Sakshi Kamboj (ORCID: https://orcid.org/0000-0001-9618-012X)
- Sidney Pals
- Jutta Meisel
Institutions
- University of Freiburg (DE)
- Max Delbrück Center (DE)
- University Medical Center Freiburg (DE)
- Humboldt-Universität zu Berlin (DE)
- German Centre for Cardiovascular Research (DE)
- European Molecular Biology Laboratory (DE)
- University of Regensburg (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1111/apha.14226
- Citations
- 8
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft