Glucosamine-Mediated Hexosamine Biosynthesis Pathway Activation Uses ATF4 to Promote “Exercise-Like” Angiogenesis and Perfusion Recovery in PAD
In cells, mice, and humans, activation of hexosamine biosynthesis pathway by glucosamine in peripheral arterial disease induces an "exercise-like" angiogenesis and offers a promising novel therapeutic pathway to treat this challenging disorder.
Authors
- Mohamed Nofal
- Brian H. Annex (ORCID: https://orcid.org/0000-0001-6538-8243)
- Abdelrahman A. Zaied (ORCID: https://orcid.org/0000-0002-2919-5329)
- Taylor C. Kress (ORCID: https://orcid.org/0000-0003-2615-3788)
- Suhib Alhusban (ORCID: https://orcid.org/0000-0002-4306-4632)
- Eric J. Belin de Chantemèle (ORCID: https://orcid.org/0000-0002-0184-3830)
- Anita Kovács‐Kása (ORCID: https://orcid.org/0000-0001-7244-5517)
- M. Murat Köseoğlu
Institutions
- Augusta University (US)
- Anna Needs Neuroblastoma Answers (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1161/circulationaha.124.069580
- Citations
- 13
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.71