Ultrasound-Induced Release Profile of Nimodipine from Drug-Loaded Block Copolymers after Singular vs. Repeated Sonication: In Vitro Analysis in Artificial Cerebrospinal Fluid
Repeated sonication resulted in an acceleration of nimodipine release from the drug-loaded copolymer in a CSF medium. These findings confirm the proof of principle of an on-demand guidance of nimodipine release from nimodipine-loaded nanodrugs by means of ultrasound, which suggests that evaluating the concept in an animal model may be appropriate.
Authors
- Vesna Malinova (ORCID: https://orcid.org/0000-0002-0062-7490)
- Frank Streit (ORCID: https://orcid.org/0000-0002-3030-5388)
- Veit Rohde (ORCID: https://orcid.org/0000-0003-3014-4307)
- Katja Döring (ORCID: https://orcid.org/0000-0002-6965-8906)
- Milena Ninković
- Heinrich Lanfermann (ORCID: https://orcid.org/0000-0002-4405-6781)
- Swetlana Sperling
- Andreas Fischer (ORCID: https://orcid.org/0000-0002-4889-0909)
Institutions
- Medizinische Hochschule Hannover (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Brain Sciences
- Published
- 2024-09-10
- DOI
- https://doi.org/10.3390/brainsci14090912
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00