Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study
Early MTX elimination t<sub>½</sub> measured within 16 h of infusion completion was significantly associated with the development of AKI and serves as an early clearance biomarker that may identify patients who benefit from increased hydration, augmented leucovorin rescue, and glucarpidase administration.
Authors
- Teresa López-Viñau (ORCID: https://orcid.org/0000-0003-3493-6969)
- Scott C. Howard (ORCID: https://orcid.org/0000-0003-2244-1686)
- Jennifer K. Lowe (ORCID: https://orcid.org/0000-0002-0010-6417)
- Laura B. Ramsey (ORCID: https://orcid.org/0000-0001-6417-3961)
- Carmelo Rizzari (ORCID: https://orcid.org/0000-0002-4828-3893)
- Zachary L. Taylor (ORCID: https://orcid.org/0000-0001-5178-2397)
- Miriam Hwang (ORCID: https://orcid.org/0000-0002-0685-4352)
- M.D. Aumente (ORCID: https://orcid.org/0000-0002-7584-924X)
- Gabriela Villanueva (ORCID: https://orcid.org/0000-0002-6159-1882)
- Nicolás Tentoni (ORCID: https://orcid.org/0000-0002-9402-5086)
- Thais Murciano
- Ryan Combs (ORCID: https://orcid.org/0000-0002-7609-0925)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Hospital Sant Joan de Déu Barcelona (ES)
- Children's Mercy Hospital (US)
- Universidad de Buenos Aires (AR)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Córdoba (ES)
- University of Milano-Bicocca (IT)
- University of Missouri–Kansas City (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.70176
- Citations
- 7
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.80