Novel insights into the association between genetically proxied inhibition of proprotein convertase subtilisin/kexin type 9 and risk of sarcopenia
This MR study suggested that PCSK9 is involved in sarcopenia pathogenesis and that its inhibition is associated with reduced ALM. These findings potentially pave the way for future studies that may allow personalized selection of lipid-lowering drugs for those at risk of sarcopenia.
Authors
- Yunxiang Chen (ORCID: https://orcid.org/0000-0002-8219-8262)
- Lijiang Zhang
- Ruimin Sun (ORCID: https://orcid.org/0000-0002-4464-1016)
- Wan‐Qiang Lv (ORCID: https://orcid.org/0000-0001-8620-8889)
- Hongyan Jiang (ORCID: https://orcid.org/0000-0003-3559-2774)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6303-5858)
- Lulu Li (ORCID: https://orcid.org/0000-0002-8891-8515)
- Xue Zhang (ORCID: https://orcid.org/0000-0001-5785-8217)
- Jia He (ORCID: https://orcid.org/0000-0003-4031-8358)
- Junxiu Liu (ORCID: https://orcid.org/0000-0003-3800-1597)
- Lijuan Xia
- Chuanhuai Chen
- Wen Lei (ORCID: https://orcid.org/0000-0002-7649-2449)
Institutions
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1002/jcsm.13575
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province