Brain and Serum Membrane Vesicle (Exosome) Profiles in Experimental Alcohol-Related Brain Degeneration: Forging the Path to Non-Invasive Liquid Biopsy Diagnostics
Chronic ethanol exposures differentially alter the expression of oligodendrocyte/myelin, astrocyte, and oxidative stress markers in the brain, brain MVs, and S-EVs. However, directionally concordant effects across all three compartments were limited. Future studies should advance these efforts by characterizing the relationship between ABRD and molecular pathological changes in brain WM-specific exosomes in serum.
Authors
- Suzanne M. de la Monte (ORCID: https://orcid.org/0000-0001-5886-2306)
- Yiwen Yang
- Ming Tong (ORCID: https://orcid.org/0000-0002-4532-5269)
Institutions
- Brown University (US)
- Rhode Island Hospital (US)
- Women & Infants Hospital of Rhode Island (US)
Publication Details
- Journal
- Journal of Molecular Pathology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.3390/jmp5030025
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- National Institutes of Health