Cathepsin C (dipeptidyl peptidase 1) inhibition in adults with bronchiectasis: AIRLEAF, a phase II randomised, double-blind, placebo-controlled, dose-finding study
Treatment with BI 1291583 resulted in a reduction in the risk of experiencing an exacerbation in adults with bronchiectasis.
Authors
- April Armstrong (ORCID: https://orcid.org/0000-0003-3729-9811)
- Michal Shteinberg (ORCID: https://orcid.org/0000-0002-0432-3398)
- Peter Eickholz (ORCID: https://orcid.org/0000-0002-1655-8055)
- Wiebke Sauter
- Naoki Hasegawa (ORCID: https://orcid.org/0000-0003-0717-7450)
- Marcus Alexander Mall (ORCID: https://orcid.org/0000-0002-4057-2199)
- James Duncan Chalmers (ORCID: https://orcid.org/0000-0001-5514-7868)
- Sanjay H. Chotirmall (ORCID: https://orcid.org/0000-0003-0417-7607)
- Anastasia G Eleftheraki (ORCID: https://orcid.org/0000-0003-1826-4699)
- Henrik Watz (ORCID: https://orcid.org/0000-0003-1506-2661)
- Pamela J. McShane (ORCID: https://orcid.org/0000-0003-1338-1407)
- Abhya Gupta (ORCID: https://orcid.org/0009-0002-5409-1561)
- Anne E. O’Donnell (ORCID: https://orcid.org/0009-0006-8066-3518)
- E. Frahm
- J. Rauch
Institutions
- Goethe University Frankfurt (DE)
- Boehringer Ingelheim (Germany) (DE)
- University of California, Los Angeles (US)
- Nanyang Technological University (SG)
- Technion – Israel Institute of Technology (IL)
- University of Dundee (GB)
- Georgetown University (US)
- Keio University (JP)
- Georgetown University Medical Center (US)
- Tan Tock Seng Hospital (SG)
- Carmel Medical Center (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
- German Center for Lung Research (DE)
- LungenClinic Grosshansdorf (DE)
- Boehringer Ingelheim (United States) (US)
- Charité - Universitätsmedizin Berlin (DE)
- The University of Texas Health Science Center at Tyler (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1183/13993003.01551-2024
- Citations
- 58
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 24.30
Funders
- Boehringer Ingelheim
- Amgen
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Teva Pharmaceutical Industries
- Chiesi Farmaceutici
- CSL Behring
- University of Dundee
- Regeneron Pharmaceuticals
- Vertex Pharmaceuticals
- Dermira
- MannKind Corporation
- INOVIO Pharmaceuticals
- Incyte
- Ortho Dermatologics
- Insmed
- York University
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Meiji Seika Pharma
- Galderma
- Deutsches Zentrum für Lungenforschung
- Sun Pharma
- Imam Abdulrahman Bin Faisal University
- Grifols
- LEO Pharma
- Genentech
- School of Medicine, New York University
- University of North Carolina at Chapel Hill
- Sanofi Genzyme
- Medical Research Council
- National Medical Research Council