A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study
The emergence of multicancer early detection (MCED) tests holds promise for improving early cancer detection and public health outcomes. However, positive MCED test results require confirmation through recommended cancer diagnostic imaging modalities. To address these challenges, we have developed a consultation and work-up protocol for definitive diagnostic results post MCED testing, named SPOT-MAS. Developed through circulating tumor DNA (ctDNA) analysis and in line with professional guidelines and advisory board consensus, this protocol standardizes information to aid general practitioners in accessing, interpreting and managing SPOT-MAS results. Clinical effectiveness is demonstrated through a series of identified cancer cases. Our research indicates that the protocol could empower healthcare professionals to confidently interpret circulating tumor DNA test results for 5 common types of cancer, thereby facilitating the clinical integration of MCED tests.
Authors
- Ha Huu Phuoc Dang
- Hoai‐Nghia Nguyen (ORCID: https://orcid.org/0000-0002-1542-1874)
- Ba Linh Tieu
- Le Son Tran (ORCID: https://orcid.org/0000-0002-5382-3903)
- Canh Duy Phan
- Van Hoi Le
- Chi Viet Bui
- Thanh Hai Phan
- Huu Nguyen Nguyen
- Van Song Tran
- Thi Van Phan
- Phan Ngoc Hong (ORCID: https://orcid.org/0000-0002-9195-1324)
- Thị Thanh Bình Nguyễn (ORCID: https://orcid.org/0000-0002-1864-3245)
- Van Thinh Cao
- Hoa Giang (ORCID: https://orcid.org/0000-0001-6549-8012)
- Binh Quang Truong (ORCID: https://orcid.org/0000-0003-4973-6919)
- Thanh Xuan Jasmine
- Minh‐Duy Phan (ORCID: https://orcid.org/0000-0002-3426-1044)
- Van Kha Vo
- Thi Thu Thuy Pham (ORCID: https://orcid.org/0009-0009-2011-0323)
- Giang Nguyen (ORCID: https://orcid.org/0000-0001-5156-4904)
- Si Tuan Nguyen
- Lưu Hồng Đăng Nguyễn (ORCID: https://orcid.org/0000-0003-2466-1164)
- Thi Kim Phuong Doan (ORCID: https://orcid.org/0000-0002-9768-4474)
- Nguyen Van Tung (ORCID: https://orcid.org/0000-0003-4624-5567)
- Dinh Kiet Truong
- Cong Thanh Truong
- Thi Huong Ly Tran
- Thi Thanh-Thuy
- Bao Toan Nguyen
- Thi Hue Hanh Nguyen
- Lan Hieu Nguyen (ORCID: https://orcid.org/0000-0003-4302-8612)
- Thanh Xuân Nguyễn (ORCID: https://orcid.org/0000-0003-3838-6300)
- Hung Sang Tang (ORCID: https://orcid.org/0009-0007-8484-4954)
- Văn Khanh Trần (ORCID: https://orcid.org/0000-0002-5059-8106)
- Vinh Bui (ORCID: https://orcid.org/0000-0002-8962-157X)
- Thi Le Quyen Le
- Minh Chi Le
- Văn Dũng Phạm (ORCID: https://orcid.org/0000-0002-2880-3898)
- Nguyen Tuong Pham (ORCID: https://orcid.org/0000-0003-4371-7581)
- Huu Thinh Nguyen (ORCID: https://orcid.org/0000-0002-0981-7274)
- Pham Thanh Nhan Nguyen
- Như Hiệp Phạm
- Minh Thien Huynh
- Huu Linh Le
- Nhung Phuong Ha
- Van Bau Phan
- Vu Tran
- Tu Quy Tran
- Thi Lan-Anh Luong
- Duy Sinh Nguyen
Institutions
- Can Tho University (VN)
- Hanoi Medical University (VN)
- Da Nang Hospital (VN)
- University Medical Center (US)
- University Medical Center HCMC (VN)
- Hue Central Hospital (VN)
- University Hospital and Clinics (US)
- Medical Genetics Center (DE)
- Vietnam National Children's Hospital (VN)
- People’s University (IN)
- Khanh Hoa General Hospital (VN)
- Agricultural Genetics Institute (VN)
- Children's Hospital 1 (VN)
- Dong Thap Hospital (VN)
Publication Details
- Journal
- Future Science OA
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1080/20565623.2024.2395244
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.86