Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease
Amygdala atrophy is not homogeneous in preclinical Alzheimer's disease (AD). Tau pathology is associated with atrophy of specific amygdala subnuclei, specifically, the central, medial, cortical, and accessory basal subnuclei. Hippocampal and amygdala volume is not associated with tau in preclinical AD. Hippocampus and CA1-3 volume is reduced in preclinical AD, regardless of tau.
Authors
- Lara Huyghe (ORCID: https://orcid.org/0009-0009-3568-3474)
- Renaud Lhommel (ORCID: https://orcid.org/0000-0003-0668-6122)
- Adrian Ivanoiu
- Thomas Gérard (ORCID: https://orcid.org/0000-0001-7997-3945)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Lisa Quenon (ORCID: https://orcid.org/0000-0001-9139-2422)
- Yasmine Salman (ORCID: https://orcid.org/0000-0002-8564-5136)
- Laurence Dricot (ORCID: https://orcid.org/0000-0002-8613-2420)
- Lise Colmant (ORCID: https://orcid.org/0009-0006-6511-0819)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- UCLouvain (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1002/alz.14235
- Citations
- 17
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Pfizer
- Merck
- Roche
- Biogen
- University of Southern California
- AbbVie
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- Fondation Louvain
- BioClinica
- Novartis Pharmaceuticals Corporation
- Takeda Pharmaceutical Company
- Northern California Institute for Research and Education
- Fonds De La Recherche Scientifique - FNRS
- Eisai
- Fondation Saint Luc
- Servier
- H. Lundbeck A/S
- IXICO
- Fondation pour la Recherche sur Alzheimer
- Walloon excellence in life sciences and biotechnology
- National Institutes of Health
- Genentech
- GE Healthcare
- Canadian Institutes of Health Research
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering