Pd-Catalyzed Deacylative [4 + 1] Annulation of <i>N</i>-Arylimidoyl Chlorides with β-Keto Esters Leading to 2-Fluoroalkyl Indoles
A palladium-catalyzed [4 + 1] annulation of <i>N</i>-arylimidoyl chlorides with β-keto esters has been developed. In the presence of Pd(OAc)<sub>2</sub>, PCy<sub>3</sub>, and K<sub>3</sub>PO<sub>4</sub>, a variety of fluoalkyl-containing <i>N</i>-arylimidoyl chlorides smoothly underwent the cascade C-H imidoylation/deacylative Heck-type reactions to afford biologically important 2-fluoroalkyl indoles in moderate to good yields.
Authors
- Zhaolun Wang (ORCID: https://orcid.org/0000-0002-1664-7971)
- Zihan Huang (ORCID: https://orcid.org/0000-0002-5781-4166)
- Hai‐Yong Tu (ORCID: https://orcid.org/0000-0002-6561-8579)
- Xing‐Guo Zhang (ORCID: https://orcid.org/0000-0002-4539-7166)
- Zhiyi Zhao
- Na Li
- Yu-Kai Shao
Institutions
- Wenzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1021/acs.joc.4c01709
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wenzhou University