Hypertension and cerebral blood flow in the development of Alzheimer's disease
Hypertension is associated with increased entorhinal cortex (EC) tau, particularly in the presence of amyloid. Decreased cortical cerebral blood flow (CBF) is associated with higher regional white matter hyperintensity volume. Increasing amyloid burden is associated with decreasing CBF in the occipital lobe. MTL CBF and amyloid are synergistically associated with EC tau.
Authors
- Dario Bachmann (ORCID: https://orcid.org/0000-0002-2863-537X)
- Lars Michels (ORCID: https://orcid.org/0000-0003-3750-1100)
- Valérie Treyer (ORCID: https://orcid.org/0000-0002-4584-3031)
- Antje Saake
- Anton Gietl (ORCID: https://orcid.org/0000-0001-8604-962X)
- Katrin Rauen (ORCID: https://orcid.org/0000-0003-4555-6697)
- Esmeralda Gruber
- Andreas Buchmann
- Roger M. Nitsch
- Christoph Höck
- Sandro Studer
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
- Swiss Institute for Regenerative Medicine (CH)
- University Hospital of Zurich (CH)
- Light Chain Bioscience (Switzerland) (CH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1002/alz.14233
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- Vontobel-Stiftung
- Mäxi-Stiftung