RAPID AND AN EFFICIENT ONE-POT THREE-COMPONENT SYNTHESIS OF ISOXAZOLES PROMOTED BY CAS

A straightforward, practical, and economical process for producing isoxazole derivatives is described. It makes use of ethylacetoacetate, hydroxylamine hydrochloride, and substituted aromatic aldehydes with promoted camphor sulfonic acid as a catalyst in a solvent. No toxic organic solvents are used in the current procedure. Shortest reaction time, high product yields, easy work-up process, and non-chromatographic product purification are only a few of this catalysts encouraging reaction response characteristics. The derivatives of desired compounds were analyzed advanced spectroscopic data by 1H NMR, 13CNMR and mass spectrometry was used to verify the products structures. Products were chosen, and their antibacterial activity was examined.