Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels

While chronic limb-threatening ischemia is a serious peripheral artery disease, the lack of an appropriate stent significantly limits the potential of interventional treatment. In spite of much progress in coronary stents, little is towards peripheral stents, which are expected to be both long and biodegradable and thus require a breakthrough in core techniques. Herein, we develop a long and biodegradable stent with a length of up to 118 mm based on a metal-polymer composite material. To achieve a well-prepared homogeneous coating on a long stent during ultrasonic spraying, a magnetic levitation is employed. In vivo degradation of the stent is investigated in rabbit abdominal aorta/iliac arteries, and its preclinical safety is evaluated in canine infrapopliteal arteries. First-in-man implantation of the stent is carried out in the below-the-knee artery. The 13 months' follow-ups demonstrate the feasibility of the long and biodegradable stent in clinical applications.

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Publication Details

Journal
Nature Communications
Published
2024-09-10
DOI
https://doi.org/10.1038/s41467-024-52288-4
Citations
14
Primary Topic
Aortic Disease and Treatment Approaches
Type
article
Field-Weighted Citation Impact
5.87

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article

Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels

Daokun Shi, Wan-Qian Zhang, Jiandong Ding, Wei Guo et al.
14 citations
Nature Communications
Aortic Disease and Treatment Approaches
5.87
article

Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels

Daokun Shi, Wan-Qian Zhang, Jiandong Ding, Wei Guo, Jingzhen Guo, Xianhua Gao, Xin Li, Haifeng Li, Hongjie Zhang, Qin Li, Gui Zhang, Deyuan Zhang, Haiping Qi, Xiaoli Shi, Guoyi Sun
article en
14 citations

Abstract

While chronic limb-threatening ischemia is a serious peripheral artery disease, the lack of an appropriate stent significantly limits the potential of interventional treatment. In spite of much progress in coronary stents, little is towards peripheral stents, which are expected to be both long and biodegradable and thus require a breakthrough in core techniques. Herein, we develop a long and biodegradable stent with a length of up to 118 mm based on a metal-polymer composite material. To achieve a well-prepared homogeneous coating on a long stent during ultrasonic spraying, a magnetic levitation is employed. In vivo degradation of the stent is investigated in rabbit abdominal aorta/iliac arteries, and its preclinical safety is evaluated in canine infrapopliteal arteries. First-in-man implantation of the stent is carried out in the below-the-knee artery. The 13 months' follow-ups demonstrate the feasibility of the long and biodegradable stent in clinical applications.

Nature CommunicationsVol. 15(1)
Fudan University (CN), Chinese PLA General Hospital (CN), Lifetech Scientific (China) (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Openalex Percentile: Top 3%
Aortic Disease and Treatment Approaches
5.87
DOIOpen Access PDFOpenAlex
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