Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast

Microbes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe, the oxylipin nitrogen signaling factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide:quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program without any change in the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients.

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Publication Details

Journal
The EMBO Journal
Published
2024-09-10
DOI
https://doi.org/10.1038/s44318-024-00224-z
Citations
8
Primary Topic
Fungal and yeast genetics research
Type
article
Field-Weighted Citation Impact
1.87

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article

Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast

Akihisa Matsuyama, Hiroaki Matoba, Hiromitsu Moriyama, Minoru Yoshida et al.
8 citations
The EMBO Journal
Fungal and yeast genetics research
1.87
article

Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast

Akihisa Matsuyama, Hiroaki Matoba, Hiromitsu Moriyama, Minoru Yoshida, Shin Ohsawa, Vytautas Iešmantavičius, Mikiko Sodeoka, Yoko Yashiroda, Go Hirai, Michaela Schwaiger, Marc Bühler, Atsushi Hashimoto, Rio Hashimoto
article en
8 citations

Abstract

Microbes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe, the oxylipin nitrogen signaling factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide:quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program without any change in the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients.

The EMBO JournalVol. 43(20)
SIB Swiss Institute of Bioinformatics (CH), Kyushu University (JP), Bunkyo University (JP), University of Basel (CH), RIKEN Center for Sustainable Resource Science (JP), Friedrich Miescher Institute (CH), The University of Tokyo (JP), Friedrich Miescher Institute (CH), Tokyo University of Agriculture and Technology (JP)
Novartis Foundation, Friedrich Miescher Institute for Biomedical Research, Ohsumi Frontier Science Foundation, Japan Society for the Promotion of Science
Openalex Percentile: Top 14%
Fungal and yeast genetics research
1.87
DOIOpen Access PDFOpenAlex
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