Exploring the effects of extracranial injections of botulinum toxin type A on activation and sensitization of central trigeminovascular neurons by cortical spreading depression in male and female rats
The ability of onabotA to prevent activation and sensitization of WDR neurons is attributed to its preferential inhibitory effects on unmyelinated C-fibers. The inability of onabotA to prevent activation of HT neurons is attributed to its less extensive inhibitory effects on the thinly myelinated Aδ-fibers. These findings provide further pre-clinical evidence about differences and potentially complementary mechanisms of action of onabotA and calcitonin gene-related peptide-signaling neutralizing drugs.
Authors
- Rami Burstein (ORCID: https://orcid.org/0000-0003-3763-8916)
- Brett Dabruzzo (ORCID: https://orcid.org/0009-0008-3048-2633)
- Andrew M. Strassman (ORCID: https://orcid.org/0000-0002-0213-3048)
- Agustin Melo‐Carrillo
- Mitchell F. Brin (ORCID: https://orcid.org/0000-0002-1989-6076)
- Aubrey Manack Adams
- Khrystoffer-Kihan J. Malcolm
- Ron S. Briode
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of California, Irvine (US)
- AbbVie (United States) (US)
- Allergan (United States) (US)
Publication Details
- Journal
- Cephalalgia
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1177/03331024241278919
- Citations
- 6
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- AbbVie
- National Institute of Neurological Disorders and Stroke