GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)
In MSA, GFAP shows promise as novel biomarker for assessing current clinical disease severity, while NfL might serve as biomarker for prediction of disease progression and differential diagnosis of MSA against PD.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Jens Wiltfang (ORCID: https://orcid.org/0000-0003-1492-5330)
- Alexander Bernhardt (ORCID: https://orcid.org/0000-0002-2572-5062)
- Aline Beyle
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Oliver Peters (ORCID: https://orcid.org/0000-0003-0568-2998)
- Martin Klietz (ORCID: https://orcid.org/0000-0002-3054-9905)
- Niels Hansen (ORCID: https://orcid.org/0000-0001-5785-9594)
- Brigitte Nuscher (ORCID: https://orcid.org/0009-0000-4661-0742)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Thomas Klockgether (ORCID: https://orcid.org/0000-0001-6174-5442)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Florian Wegner (ORCID: https://orcid.org/0000-0002-9931-2666)
- Urban M. Fietzek (ORCID: https://orcid.org/0000-0002-4323-9930)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Björn Falkenburger (ORCID: https://orcid.org/0000-0002-2387-526X)
- Sabrina Katzdobler (ORCID: https://orcid.org/0000-0002-3512-5984)
- Christian Haass (ORCID: https://orcid.org/0000-0002-4869-1627)
- Thomas Gasser (ORCID: https://orcid.org/0000-0002-1069-1146)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Meret K. Huber
- Georg Nübling
- Anja Schneider (ORCID: https://orcid.org/0000-0001-9540-8700)
- Daniel C. Hoffmann (ORCID: https://orcid.org/0000-0002-6975-8819)
- Luisa‐Sophie Schneider (ORCID: https://orcid.org/0000-0001-5822-1744)
- Ina R. Vogt (ORCID: https://orcid.org/0000-0002-2183-6937)
- Wenzel Glanz (ORCID: https://orcid.org/0000-0002-5865-4176)
- Sophia Rogozinski
- Moritz Brandt (ORCID: https://orcid.org/0000-0001-7686-7485)
- Eike Jakob Spruth
Institutions
- University of Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Dassault Systèmes (Germany) (DE)
- Munich Cluster for Systems Neurology (DE)
- IONICS Mass Spectrometry (Canada) (CA)
- UK Dementia Research Institute (GB)
- University Hospital Magdeburg (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University College London (GB)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1007/s00415-024-12647-z
- Citations
- 17
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- Deutsche Forschungsgemeinschaft
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Anton and Petra Ehrmann-Stiftung